Pathophysiological roles and clinical importance of biomarkers in acute coronary syndrome

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Published on: January 28, 2020

Cangel Pui-Yee Chan1, Timothy Hudson Rainer

  • 1Accident and Emergency Medicine Academic Unit, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, NT, Hong Kong SAR, PR China. cangelchan@cuhk.edu.hk

Advances in Clinical Chemistry
|March 7, 2013
PubMed

Insights

Early diagnosis of acute coronary syndrome (ACS) is crucial for timely treatment. Emerging biomarkers show promise for earlier risk assessment and improved patient management, though further evaluation is needed.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Early diagnosis of acute coronary syndrome (ACS) is critical for effective therapy.
  • Accurate risk stratification guides resource allocation for diagnostic tests and interventions.
  • Biomarkers play a key role in assessing patient risk and predicting adverse events.

Purpose of the Study:

  • To review the pathophysiology and clinical utility of established and emerging biomarkers for ACS.
  • To highlight biomarkers that may enable earlier risk assessment in ACS patients.

Main Methods:

  • Literature review of pathophysiology and clinical characteristics of ACS biomarkers.
  • Analysis of established and emerging biomarkers for plaque destabilization, ischemia, necrosis, and dysfunction.

Main Results:

  • Biomarkers upstream of acute-phase markers may offer earlier risk assessment.
  • Emerging biomarkers show potential for identifying high-risk ACS patients.
  • Established biomarkers aid in risk stratification and guiding interventions.

Conclusions:

  • Biomarkers are essential for early ACS diagnosis and risk stratification.
  • Emerging biomarkers hold promise for earlier and more accurate patient assessment.
  • Further research is required to validate emerging biomarkers for routine clinical use.

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