Prostate-specific antigen density: a better index of obesity-related PSA decrease in ostensibly healthy Korean men...

Area of Science:

• Urology
• Endocrinology
• Public Health

Background:

• Obesity is a growing global health concern.
• The relationship between obesity and prostate health requires further investigation.
• Prostate-specific antigen (PSA) and prostate-specific antigen density (PSAD) are key biomarkers for prostate health.

Purpose of the Study:

• To compare the correlation between obesity and prostate-specific antigen density (PSAD) versus prostate-specific antigen (PSA).
• To assess the impact of Body Mass Index (BMI) on PSA and PSAD levels in Korean men.

Main Methods:

• A cohort of 2402 Korean men over 40 underwent prostate examinations.
• Data collected included anthropometric measurements, PSA levels, and transrectal ultrasound.
• Statistical analyses, including partial correlation and linear trend models, were used, adjusting for age.

Main Results:

• A significant negative correlation was observed between BMI and both PSA and PSAD.
• PSAD demonstrated a significant linear trend across all BMI groups.
• PSA showed a significant linear trend only in the obese BMI group (≥ 25 kg/m²).

Conclusions:

• Prostate-specific antigen density (PSAD) exhibits a more significant negative correlation with obesity than PSA.
• PSAD may be a more sensitive indicator of the relationship between obesity and prostate health compared to PSA.