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Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
The Pineal Gland01:02

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The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
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Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Melatonin and human skin aging.

Konrad Kleszczynski1, Tobias W Fischer

  • 1Department of Dermatology; University of Lübeck; Lübeck, Germany.

Dermato-Endocrinology
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Melatonin, a pineal gland hormone, acts as a potent antioxidant. This review highlights its potential as an effective anti-skin aging compound by counteracting UV-induced damage and reactive oxygen species.

Keywords:
antioxidative enzymesapoptosismelatoninmitochondrial damageoxidative stressskinultraviolet radiation

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Area of Science:

  • Dermatology
  • Endocrinology
  • Biochemistry

Background:

  • Skin aging is influenced by internal and environmental factors, notably solar radiation.
  • Melatonin, a hormone secreted by the pineal gland, regulates circadian rhythms.
  • Melatonin receptors are present in various skin cell types, including keratinocytes, melanocytes, and fibroblasts.

Purpose of the Study:

  • To review the role of melatonin as an anti-skin aging agent.
  • To explore melatonin's antioxidative and protective mechanisms against UV-induced skin damage.

Main Methods:

  • Literature review of experimental studies on melatonin and skin aging.
  • Analysis of melatonin's effects on reactive oxygen species, mitochondrial damage, and DNA damage.

Main Results:

  • Melatonin exhibits significant antioxidative activity.
  • It effectively counteracts the generation of reactive oxygen species induced by UV radiation.
  • Melatonin mitigates mitochondrial and DNA damage caused by solar exposure.

Conclusions:

  • Melatonin demonstrates considerable potential as an effective anti-skin aging compound.
  • Its antioxidative properties are key to protecting skin from environmental damage.
  • Further research into melatonin's therapeutic applications for skin aging is warranted.