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Updated: May 13, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
3-[(Furan-2-yl)carbon-yl]-1-(pyrimi-din-2-yl)thio-urea
Durga P Singh1, Seema Pratap, Sushil K Gupta
1Department of Chemistry, M.M.V., Banaras Hindu University, Varanasi 221 005, India.
Abstract:
The title compound, C10H8N4O2S, was synthesized from furoyl isothio-cynate and 2-amino-pyrimidine in dry acetone. The two N-H groups are in an anti conformation with respect to each other and one N-H group is anti to the C=S group while the other is syn. The amide C=S and the C=O groups are syn to each other. The mean plane of the central thio-urea fragment forms dihedral angles of 13.50 (14) and 5.03 (11)° with the furan and pyrimidine rings, respectively. The dihedral angle between the furan and pyrimidine rings is 18.43 (10)°. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯N hydrogen bond generating an S(6) ring motif. In the crystal, mol-ecules are linked by pairs of N-H⋯N and weak C-H⋯S hydrogen bonds to form inversion dimers.
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