Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

What is the Skeletal System?

What is the Skeletal System?

The Functions of the Skeletal System

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women.

Aging medicine (Milton (N.S.W))·2022

Same author

Comparison of femoral neck geometric parameters between Chinese and Japanese females.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2022

Same author

The Characteristics of Iodine Nutrition Status in China After 20 Years of Universal Salt Iodization: An Epidemiology Study Covering 31 Provinces.

Thyroid : official journal of the American Thyroid Association·2021

Same author

The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.

Endocrinology and metabolism (Seoul, Korea)·2021

Same author

Hyperthyroidism Prevalence in China After Universal Salt Iodization.

Frontiers in endocrinology·2021

Same author

The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2021

Search research articles

Related Experiment Video

Updated: May 13, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

FGF23 associated bone diseases.

¹Institute of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, Changsha, 410011, China. eyliao007@yahoo.com.cn

Frontiers of Medicine

|March 9, 2013

Summary

This summary is machine-generated.

Fibroblast growth factor 23 (FGF23) is crucial for phosphate and vitamin D regulation. This review covers FGF23

More Related Videos

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Published on: October 18, 2018

Related Experiment Videos

Last Updated: May 13, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Published on: October 18, 2018

Area of Science:

Endocrinology
Metabolic Bone Diseases

Background:

Fibroblast growth factor 23 (FGF23) is a key hormone.
FGF23 plays a significant role in phosphate and vitamin D metabolism.
Dysregulation of FGF23 is implicated in various bone diseases.

Purpose of the Study:

To review the FGF superfamily.
To elucidate the mechanism of FGF23 in phosphate and vitamin D metabolism.
To discuss FGF23-related bone diseases.

Main Methods:

Literature review of FGF23 research.
Synthesis of information on FGF23 function.
Analysis of FGF23's role in bone pathology.

Main Results:

Overview of FGF superfamily members.
Detailed explanation of FGF23's regulatory pathways for phosphate and vitamin D.
Categorization of bone diseases associated with FGF23 abnormalities.

Conclusions:

FGF23 is a critical regulator of mineral metabolism.
Understanding FGF23 mechanisms is vital for diagnosing and treating related bone disorders.
Further research into FGF23 pathways may reveal new therapeutic targets.