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Updated: May 13, 2026
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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
North American Contact Dermatitis Group patch test results: 2009 to 2010
Erin M Warshaw1, Donald V Belsito, James S Taylor
1Department of Dermatology, Minneapolis VA Health Care System and University of Minnesota, Minneapolis, MN, USA. erin.warshaw@med.va.gov
Dermatitis : Contact, Atopic, Occupational, Drug
|March 12, 2013
Summary
Patch testing is crucial for diagnosing allergic contact dermatitis. This study analyzed North American Contact Dermatitis Group (NACDG) data, revealing decreased reactions to some allergens but increased reactions to others like fragrance mix II.
Area of Science:
- Dermatology
- Allergology
- Epidemiology
Background:
- Patch testing is a key diagnostic method for identifying allergens causing allergic contact dermatitis.
- Allergic contact dermatitis affects a significant portion of the population, necessitating accurate diagnostic tools.
Purpose of the Study:
- To report the patch testing results from the North American Contact Dermatitis Group (NACDG) for the period of January 1, 2009, to December 31, 2010.
- To analyze trends in allergic reactions to specific allergens over time.
Main Methods:
- Standardized patch testing with a screening series of 70 allergens was conducted at 12 North American centers.
- Data from 4308 patients were collected, manually verified, and entered into a central database.
- Descriptive frequencies and trend analyses using chi-squared statistics were performed.
Main Results:
- Over 60% of patients exhibited at least one positive patch test reaction.
- Allergic contact dermatitis was the primary diagnosis for 46.3% of patients.
- Statistically significant decreases in positive reaction rates were observed for 20 allergens, while rates increased for 4 allergens, including fragrance mix II and iodopropynyl butylcarbamate.
Conclusions:
- Patch testing remains a valuable diagnostic tool for a wide range of allergens.
- The study highlights evolving trends in allergen sensitization, underscoring the need for updated testing series.
