Related Experiment Videos
Genophenotypic analysis of angiotensinogen gene M235T polymorphism and preeclampsia
O V Radkov1, M N Kalinkin, V V Zavarin
1Tver' State Medical Academy, Ministry of Health Care and Social Development of the Russian Federation, Russia. unag@mail.ru
Abstract:
We studied phenotypes of the circulating renin-angiotensin-aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T. The TT genotype or T allele of angiotensinogen M235T gene polymorphism is associated with the risk of preeclampsia. Plasma renin activity significantly decreases under conditions of preeclampsia. The TT genotype of angiotensin M235T gene polymorphism is associated with highest renin activity and highest 24-h diastolic BP in comparison with MT and MM genotypes in patients with preeclampsia. Plasma aldosterone level is lower in patients with preeclampsia, but this is not related to angiotensinogen M235T gene polymorphism.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pharmacogenomics: Identification of New Drug Targets
Teratogenicity
Epistasis Analysis