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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

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Updated: May 13, 2026

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
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Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

DNA nanotechnology: a future perspective.

Muniza Zahid1, Byeonghoon Kim, Rafaqat Hussain

  • 1Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore 54000, Pakistan. ramin@ciitlahore.edu.pk.

Nanoscale Research Letters
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

DNA nanotechnology utilizes DNA

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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Area of Science:

  • Biotechnology
  • Materials Science
  • Nanotechnology

Background:

  • DNA's genetic function extends to its role as a sophisticated self-assembling nanomaterial.
  • DNA nanotechnology leverages predictable oligonucleotide self-assembly for novel nanostructure design.
  • DNA's base pairing (A-T, G-C) enables programmable and precise nanoarchitectures.

Purpose of the Study:

  • To highlight DNA's potential as a programmable nanomaterial.
  • To explore the mechanisms of DNA-based nanoassembly.
  • To underscore the multidisciplinary applications of DNA nanotechnology.

Main Methods:

  • Exploiting DNA base pairing complementarity for self-assembly.
  • Utilizing DNA crossover junctions to create ordered motifs.
  • Designing DNA oligonucleotides for specific nanostructure formation.

Main Results:

  • Demonstration of DNA's capability to form highly ordered nanostructures.
  • Assembly of larger structures through the strategic association of DNA helices and crossover junctions.
  • Establishment of DNA as a versatile framework for advanced nanofabrications.

Conclusions:

  • DNA nanotechnology offers an intelligent approach to creating programmable nanoarchitectures.
  • The unique properties of DNA facilitate its application across diverse fields.
  • DNA's self-assembly characteristics pave the way for innovations in biomedicine, computer science, and nano/optoelectronics.