Related Experiment Video
Updated: May 13, 2026

03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Sarcopenia and its determinants among Iranian elderly (SARIR): study protocol.
Rezvan Hashemi1, Ramin Heshmat, Ahmadreza Dorosty Motlagh
1Endocrinology and metabolic research center, and chronic disease research center, Tehran University of Medical Science, Tehran, Iran. rheshmat@tums.ac.ir.
Journal of Diabetes and Metabolic Disorders
|March 19, 2013
Summary
This study is the first in Iran to evaluate sarcopenia, an age-related loss of muscle mass, and its risk factors in the elderly. Findings will inform public health strategies to improve senior health and independence.
Area of Science:
- Gerontology and Public Health
- Geriatric Medicine
- Nutritional Science
Background:
- Global increase in elderly populations necessitates focus on senior health and independence.
- Aging is associated with body composition changes, including muscle mass loss (sarcopenia), leading to functional impairment.
- Sarcopenia definitions vary; the European Working Group's 2010 definition considers muscle mass and function.
Purpose of the Study:
- To evaluate sarcopenia prevalence and associated risk factors in Iranian elderly using the new definition.
- To establish a baseline for sarcopenia research in Iran, a country with a rapidly growing elderly population.
Main Methods:
- Two-phase study in Tehran elderly (≥55 years): cross-sectional for frequency, case-control for metabolic/inflammatory factors.
- Case finding for the second phase.
- Factor analysis to assess the association between sarcopenia and dietary patterns.
Main Results:
- This section is to be filled after the study is conducted.
Conclusions:
- This study is the first to assess sarcopenia and risk factors in Iranian elders.
- Detailed methodology for data collection, measurement of muscle parameters, and defining sarcopenia in the Iranian context will be discussed.
- Results aim to guide health policy for elderly well-being and quality of life.
Related Concept Videos
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
