Related Experiment Video
Updated: May 13, 2026
07:12
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Endometriosis: a life cycle approach?
Ivo Brosens1, Patrick Puttemans, Giuseppe Benagiano
1Catholic University Leuven, Leuven, Belgium; Leuven Institute for Fertility and Embryology, Leuven, Belgium.
American Journal of Obstetrics and Gynecology
|March 19, 2013
Summary
This study presents a life cycle approach to understanding endometriosis, distinguishing three age-related stages: premenarcheal/adolescent, adult, and postmenopause. It reveals new insights into the disease
Area of Science:
- Reproductive Medicine
- Gynecology
- Pathology
Background:
- Endometriosis understanding remains fragmented.
- A life cycle approach offers new insights into its natural history.
Purpose of the Study:
- To delineate age-related stages of endometriosis.
- To explore the pathogenesis and manifestations across a woman's life.
Main Methods:
- Life cycle analysis of endometriosis.
- Distinguishing three age-related disease stages: premenarcheal/adolescent, adult, and postmenopause.
Main Results:
- Premenarcheal/adolescent endometriosis presents in classic or congenital obstructive forms.
- Adult endometriosis involves peritoneal, ovarian, deep, or adenomyotic lesions, linked to uterine changes.
- Postmenopausal endometriosis can reactivate and spread, causing constrictive lesions.
Conclusions:
- Endometriosis exhibits distinct characteristics and potential origins across different life stages.
- Understanding these stages is crucial for improved diagnosis and management of endometriosis.
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