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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
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Development of a "signal-on" electrochemical DNA sensor with an oligo-thymine spacer for point mutation detection
1Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Chemical Communications (Cambridge, England)
|March 19, 2013
Abstract:
We report a reagentless and reusable "signal-on" electrochemical DNA sensor that utilizes oligo-thymine as a flexible spacer. This sensor design is sensitive, specific, and selective; it is potentially generalizable for detection of a wide range of biomedical-relevant nucleic acid sequences.
