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Related Experiment Video

Updated: May 13, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Microcirculation in sepsis: new perspectives.

Glenn Hernandez¹, Alejandro Bruhn, Can Ince

¹Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Current Vascular Pharmacology

|March 20, 2013

Summary

This summary is machine-generated.

Microcirculatory dysfunction is central to septic shock, impacting organ flow and prognosis. Assessing microcirculation bedside aids in identifying severe cases and guiding targeted therapies for better patient outcomes.

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A Data-Driven Approach to Quantifying Immune States in Sepsis

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Published on: February 7, 2025

Area of Science:

Critical Care Medicine
Hemodynamics
Pathophysiology

Background:

Microcirculatory dysfunction is a key factor in sepsis evolution.
The microcirculation regulates and distributes blood flow to organs.
Dysfunction in septic shock arises from endothelial issues, inflammation, and coagulation problems.

Purpose of the Study:

To review pathogenic mechanisms of microcirculatory abnormalities in septic shock.
To discuss technological assessment and clinical correlates of microcirculatory dysfunction.
To explore potential therapies targeting microcirculation in sepsis.

Main Methods:

Review of current literature on microcirculatory dysfunction in septic shock.
Discussion of pathogenic mechanisms, including endothelial dysfunction and inflammation.
Analysis of bedside assessment techniques and their clinical relevance.

Main Results:

Microcirculatory abnormalities are linked to poor prognosis and are not always predicted by systemic variables.
Bedside techniques enable functional hemodynamic monitoring and staging of microcirculatory severity.
High norepinephrine requirements and hyperlactatemia correlate with significant microcirculatory derangements.

Conclusions:

Clinically relevant microcirculatory abnormalities can be defined and staged.
Severe septic shock patients with microcirculatory derangements are ideal candidates for targeted interventions.
Further research is needed to confirm if microcirculation-focused therapies improve outcomes in critically ill patients.