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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: May 13, 2026

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
13:16

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

Published on: January 4, 2013

Brain perfusion in sepsis.

Fabio Silvio Taccone1, Sabino Scolletta, Federico Franchi

  • 1Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium. ftaccone@ulb.ac.be

Current Vascular Pharmacology
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Sepsis-associated encephalopathy (SAE) involves complex brain dysfunction. This review explores how altered cerebral blood flow (CBF) and impaired autoregulation contribute to SAE, focusing on human studies and monitoring tools.

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Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
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Published on: December 10, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
13:16

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Published on: January 4, 2013

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Sepsis-associated encephalopathy (SAE) is a common neurological complication of sepsis.
  • The precise mechanisms underlying SAE remain incompletely understood.
  • Altered cerebral blood flow (CBF) is implicated in SAE development.

Purpose of the Study:

  • To review the pathophysiology of brain perfusion in sepsis.
  • To focus on human clinical investigations of SAE.
  • To highlight novel tools for monitoring CBF in septic patients.

Main Methods:

  • Literature review focusing on human studies.
  • Analysis of mechanisms affecting cerebral blood flow (CBF) in sepsis.
  • Discussion of cerebral autoregulation and microcirculation in SAE.

Main Results:

  • Reduced CBF, caused by vasoconstriction and endothelial dysfunction, is a key factor in SAE.
  • Impaired cerebral autoregulation in septic patients compromises brain perfusion.
  • Cerebral microcirculatory dysfunction may contribute to neurological deficits in sepsis.

Conclusions:

  • Altered CBF and impaired autoregulation are significant contributors to SAE pathophysiology.
  • Further research is needed to fully elucidate the role of brain perfusion in SAE.
  • Novel CBF monitoring tools are crucial for understanding and managing SAE.