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Updated: May 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Natural history and outcomes of atrial fibrillation]
François Brigadeau1, Dominique Lacroix
1Hôpital cardiologique, CHRU de Lille, 59037 Lille Cedex, France. f-brigadeau@chru-lille.fr
Insights
Atrial fibrillation (AF) often presents without symptoms, but its complications like stroke and heart failure significantly increase mortality risk. Antithrombotic treatment for AF focuses on overall risk, not symptom perception.
Area of Science:
- Cardiology
- Neurology
Context:
- Atrial fibrillation (AF) frequently occurs asymptomatically, with the initial presentation potentially being a severe complication.
- The progression of AF from paroxysmal to persistent forms is unpredictable.
- Antithrombotic therapy decisions in AF are based on global thromboembolic risk assessment, independent of patient-reported symptoms or rhythm status.
Purpose:
- To highlight the silent nature of atrial fibrillation and its potential for severe, unheralded complications.
- To underscore the critical link between atrial fibrillation and major adverse events, including stroke and heart failure.
Summary:
- Atrial fibrillation (AF) often lacks early symptoms, with the first manifestation frequently being a stroke.
- AF-related strokes are associated with high mortality and can contribute to cognitive decline.
- Heart failure is another common complication of AF, sharing etiological factors and contributing to increased mortality.
- While less life-threatening, AF significantly impairs quality of life and leads to frequent hospitalizations.
Impact:
- Emphasizes the need for proactive risk assessment and management in all patients with atrial fibrillation, regardless of symptoms.
- Underscores the severe consequences of AF, including stroke and heart failure, which elevate overall mortality.
- Highlights the significant impact of AF on patient quality of life and healthcare utilization.
Abstract:
Atrial fibrillation occurs most of the time without any symptom. The first symptomatic episode may follow many silent episodes. The natural history of atrial fibrillation is relatively chaotic from paroxysmal to persistent and permanent atrial fibrillation. The consequence is that antithrombotic treatment depends on global thromboembolic risk and not on patient's perception of arrhythmia or sinus rhythm presentation. Unfortunately, the first appearance may be the most feared complication: stroke. Stroke due to atrial fibrillation are frequent, severe, with high mortality rate during hospitalization and during the following year. The severity of stroke during atrial fibrillation could explain a certain degree of cognitive decline. Heart failure is also a frequent atrial fibrillation complication due to sharing of common causes. Through those two complications, atrial fibrillation raises mortality rate. Less importantly, though leading to frequent hospitalizations, quality of life impairment is relatively frequent.
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