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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Management of hyperparathyroidism (PHP) in MEN2 syndromes in Europe
1Endocrine Unit, Evgenidion Hospital and Dept Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 11528 Athens, Greece. mani@otenet.gr.
Abstract:
Hyperparathyroidism occurs in 20-30% of MEN2A syndrome patients. It is usually associated with mild disease and is frequently asymptomatic, especially in younger age. There is genotype/phenotype association and PHP is usually associated with codon 634 mutations; however association with more "rare" mutations has also been reported. The pathology of the parathyroid glands includes hyperplasia, adenoma or a combination of the two. The optimal surgical management of this entity has not been defined yet.
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