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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
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Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

Environment and the inflammatory bowel diseases.

Alexandra Frolkis, Levinus A Dieleman, Herman W Barkema

    Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
    |March 22, 2013
    PubMed
    Summary

    Environmental factors like smoking and diet may influence inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis. Research highlights inconsistent findings, emphasizing the need for further investigation into IBD

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    Published on: April 21, 2015

    Area of Science:

    • Gastroenterology
    • Immunology
    • Epidemiology

    Background:

    • Inflammatory bowel diseases (IBD), encompassing Crohn disease and ulcerative colitis, are chronic gastrointestinal inflammatory conditions.
    • Increasing incidence of IBD observed globally over the past century.
    • Pathogenesis is linked to genetic susceptibility, environmental factors, and gut microbiota interactions.

    Purpose of the Study:

    • To review and synthesize current knowledge on environmental risk factors associated with IBD.
    • To consolidate findings on various potential environmental triggers for IBD development.

    Main Methods:

    • Comprehensive literature review of studies investigating environmental factors and IBD.
    • Analysis of research on risk factors including smoking, hygiene, diet, and infections.

    Main Results:

    • Identified numerous environmental factors implicated in IBD etiology, such as smoking, diet, and infections.
    • Observed inconsistent findings across studies, suggesting a complex interplay of factors.
    • Highlighted the role of hygiene, oral contraceptives, antibiotics, breastfeeding, geography, pollution, and stress.

    Conclusions:

    • The etiology of IBD is complex and multifactorial, involving a combination of genetic and environmental influences.
    • Further research is essential to clarify the precise role and mechanisms of environmental factors in IBD pathogenesis.
    • Additional studies are needed to identify and elucidate specific environmental triggers for IBD.