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Relationship between hematologic parameters and left ventricular systolic dysfunction in stable patients with

Orhan Doğdu1, Mahmut Akpek, Mikail Yarlıoğlueş

  • 1Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey. orhandogdu@yahoo.com

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|March 23, 2013
PubMed

Insights

The neutrophil-to-lymphocyte ratio (N/L ratio) and high-sensitivity C-reactive protein (hs-CRP) are linked to reduced left ventricular systolic function in multi-vessel coronary artery disease (MVCAD) patients. These inexpensive markers can predict impaired heart function in stable MVCAD.

Area of Science:

  • Cardiology
  • Hematology
  • Internal Medicine

Background:

  • Multi-vessel coronary artery disease (MVCAD) is a significant predictor of adverse outcomes in patients with chronic stable angina.
  • Left ventricular systolic function is crucial for cardiac health and prognosis.

Purpose of the Study:

  • To investigate the association between hematologic parameters and impaired left ventricular systolic function in patients with stable MVCAD.
  • To identify potential biomarkers for predicting left ventricular dysfunction in this patient group.

Main Methods:

  • A cohort of 202 patients with stable angina and MVCAD was analyzed.
  • Patients were categorized into preserved (LVEF >50%) and impaired (LVEF <50%) left ventricular ejection fraction (LVEF) groups based on echocardiography.
  • Hematologic parameters, including hs-CRP and N/L ratio, were compared between groups.

Main Results:

  • The impaired LVEF group had higher frequencies of diabetes mellitus, elevated hs-CRP levels, and increased N/L ratios compared to the preserved group.
  • Significant negative correlations were observed between LVEF and both hs-CRP and N/L ratio.
  • N/L ratio >3.0 demonstrated 77% sensitivity and 68% specificity for predicting left ventricular dysfunction and was identified as an independent predictor.

Conclusions:

  • Neutrophil-to-lymphocyte ratio (N/L ratio) and high-sensitivity C-reactive protein (hs-CRP) are independently associated with impaired left ventricular systolic function in stable MVCAD.
  • These easily measurable and inexpensive laboratory markers can aid in identifying patients at risk for left ventricular dysfunction.
Abstract

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