[Obesity and skeletal muscle remodeling]

Obesity represents a condition where the management of nutrients and energy status presents significant challenges at the organismic levels. Obesity caused the following changes of skeletal muscle in function and structure: metabolism, the number and function of mitochondria, muscle fiber type, capillary density and recruitment, the extracellular matrix and muscle streath and power, induced the skeletal muscle remodeling. Skeletal muscle is the place of metabolism and the movement system. Rencent studies indicated that skeletal muscle can secrete myokines, and be considered as the biggest endocrine organ according to mass, thus skeletal muscle remodeling has important physiological and pathophysiological significance.