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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 13, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Electrophysiology and glaucoma: current status and future challenges.

Michael Bach1, Charlotte M Poloschek

  • 1Section Visual Function, Department of Ophthalmology, University of Freiburg, Freiburg, Germany. michael.bach@uni-freiburg.de

Cell and Tissue Research
|March 26, 2013
PubMed
Summary

The pattern electroretinogram (PERG) and photopic negative response (PhNR) offer superior insights into glaucoma compared to the multifocal ERG. PERG shows promise for early glaucoma detection.

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Related Experiment Videos

Last Updated: May 13, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

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Published on: March 12, 2016

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Published on: May 25, 2020

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Visual electrophysiology offers non-invasive assessment of the visual pathway.
  • Glaucomatous optic nerve disease affects retinal ganglion cells.
  • Evaluating electrophysiological methods for glaucoma diagnosis is crucial.

Purpose of the Study:

  • To determine the most informative visual electrophysiology methods for assessing glaucomatous optic nerve disease.
  • To compare the utility of multifocal ERG, pattern ERG (PERG), and photopic negative response (PhNR).

Main Methods:

  • Review and comparison of existing literature on visual electrophysiology in glaucoma.
  • Analysis of the sensitivity of multifocal ERG, PERG, and PhNR to glaucomatous changes.
  • Consideration of longitudinal data and topographic resolution for diagnostic value.

Main Results:

  • The multifocal ERG is less affected by glaucoma than PERG and PhNR, which directly measure retinal ganglion cell function.
  • Longitudinal studies suggest PERG can aid in early glaucoma detection; PhNR lacks such data.
  • Multifocal PERG's topographic resolution offers no advantage in glaucoma due to panretinal changes.

Conclusions:

  • PERG and PhNR are more informative than multifocal ERG for evaluating glaucomatous optic nerve disease.
  • PERG demonstrates potential for early glaucoma detection.
  • Further longitudinal studies are needed for PhNR, and multifocal visual evoked potential requires standardization for routine use.