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Role of plasmacytoid dendritic cells in breast cancer bone dissemination
Anandi Sawant1, Selvarangan Ponnazhagan
1Department of Pathology; The University of Alabama at Birmingham; Birmingham, AL USA.
Oncoimmunology
|March 26, 2013
Abstract:
Elevated levels of plasmacytoid dendritic cells (pDC) have been observed as breast cancer disseminates to the bone. The selective depletion of pDC in mice led to a total abrogation of bone metastasis as well as to an increase in TH1 antitumor response, suggesting that pDC may be considered as a potential therapeutic target for metastatic breast cancer.
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