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IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models

Sara Fritzell1, Sofia Eberstål, Emma Sandén

  • 1Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden. sara.fritzell@med.lu.se

Journal of Neuroimmunology
|March 27, 2013
PubMed

Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.

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