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Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
Published on: June 23, 2018
[Antioxidant activity of cationic whey protein isolate]
Voprosy Pitaniia
|March 28, 2013
Summary
Cationic whey protein isolate demonstrates significant antioxidant activity by reducing lipid peroxidation in both in vitro and in vivo models. This isolate, rich in beneficial proteins, shows potential for regulating oxidative stress in biological systems.
Area of Science:
- Biochemistry
- Food Science
- Cell Biology
Context:
- Lipid peroxidation (LPO) is a free radical mechanism damaging biological membranes.
- Biological fluids contain complex bioactive substances with protective functions.
- Whey protein isolates are a source of valuable multifunctional proteins.
Purpose:
- To investigate the antioxidant activity of cationic whey protein isolate.
- To evaluate the efficacy of this isolate in vitro and in vivo models of lipid peroxidation.
Summary:
- Cationic whey protein isolate, containing lactoperoxidase, lactoferrin, and lysozyme, was isolated from cow's milk.
- In vitro studies showed the isolate significantly reduced lipid peroxidation products in model systems.
- In vivo studies with rats demonstrated a >20% decrease in blood lipid peroxidation products after oral administration.
Impact:
- Cationic whey protein isolate exhibits notable antioxidant effects, regulating lipid oxidation intensity.
- This isolate holds potential as a natural antioxidant agent in food and therapeutic applications.
- Further research can explore its role in managing oxidative stress-related conditions.
