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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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Updated: May 12, 2026

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

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Published on: March 28, 2018

Systemic causes of cholestasis.

Andrew S Delemos1, Lawrence S Friedman

  • 1Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Clinics in Liver Disease
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Systemic diseases can cause cholestasis (impaired bile flow) through direct liver damage or immune responses. Evaluating patients involves assessing risk factors, clinical presentation, and lab results to identify these underlying causes.

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Related Experiment Videos

Last Updated: May 12, 2026

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

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Published on: March 28, 2018

Creation of Reversible Cholestatic Rat Model
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Area of Science:

  • Hepatology
  • Internal Medicine
  • Immunology

Background:

  • Cholestasis, a condition of impaired bile flow, can stem from diverse systemic diseases affecting various organ systems.
  • Pathophysiology involves direct hepatic or biliary involvement or secondary immune-mediated alterations in bile flow.

Purpose of the Study:

  • To outline the systemic causes of cholestasis.
  • To emphasize the importance of a comprehensive evaluation for identifying underlying systemic etiologies.

Main Methods:

  • Review of systemic diseases that manifest with cholestasis.
  • Analysis of the pathophysiological mechanisms linking systemic conditions to cholestasis.
  • Discussion of clinical evaluation strategies for patients with cholestasis.

Main Results:

  • Systemic diseases present a broad spectrum of cholestasis causes.
  • Evaluation requires integrating patient history, clinical context, symptoms, and laboratory findings.
  • Understanding risk factors and clinical settings is crucial for diagnosis.

Conclusions:

  • Systemic conditions are significant contributors to cholestasis.
  • A thorough, multi-faceted diagnostic approach is essential for accurate identification and management of systemic cholestasis.