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Published on: August 11, 2018
Self-assembled potential bio nanocarriers for drug delivery
Nasima Akter1, Shahidan Radiman, Faizal Mohamed
1School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia. nasima.physics@yahoo.com
Bio-surfactants offer superior, eco-friendly options for self-assembled nanocarriers in drug delivery. Their versatile structures and properties make them ideal for creating effective drug delivery vehicles.
Area of Science:
- Biotechnology
- Materials Science
- Nanotechnology
Background:
- Self-assembled nanocarriers are crucial for drug delivery applications.
- Surfactant selection is key for successful nanocarrier preparation.
- Phospholipid and synthetic surfactants have limitations in complex in-vivo environments.
Purpose of the Study:
- To review the properties and applications of bio-nano-carriers for drug delivery.
- To highlight the advantages of bio-surfactants over synthetic alternatives.
- To discuss micelle, microemulsion, and vesicle nanocarrier structures.
Main Methods:
- Literature review focusing on bio-surfactants and nanocarrier systems.
- Analysis of molecular structures and self-assembly properties of bio-surfactants.
- Evaluation of bio-nano-carriers for drug delivery efficacy and stability.
Main Results:
- Bio-surfactants exhibit advantageous properties like bio-origin, low toxicity, biodegradability, and cost-effectiveness.
- Their versatile molecular structures facilitate self-assembly into various nanostructures.
- Bio-nano-carriers demonstrate enhanced DNA binding, pH sensitivity, and stability compared to synthetic counterparts.
Conclusions:
- Bio-surfactants are highly suitable for developing advanced drug delivery systems.
- The unique properties of bio-nano-carriers offer novel solutions for drug delivery challenges.
- Micelles, microemulsions, and vesicles formed by bio-surfactants show significant potential in pharmaceutical applications.
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