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Left ventricular diastolic dysfunction in type 1 (insulin-dependent) diabetic patients during dynamic exercise
G Jermendy1, S Khoór, M Z Koltai
1István City Hospital, Merényi Medical Department, Budapest, Hungary.
Cardiology
|January 1, 1990
Summary
Type 1 diabetes patients may have exercise-induced diastolic dysfunction, even without overt heart disease. Early detection using mechanocardiography after exercise is crucial for identifying these silent cardiac changes.
Area of Science:
- Cardiology
- Diabetology
- Biomedical Engineering
Background:
- Type 1 diabetes is associated with cardiovascular complications.
- Subtle cardiac changes may precede overt heart disease in diabetic patients.
Purpose of the Study:
- To assess left ventricular diastolic and systolic functions in type 1 diabetic patients without overt heart disease.
- To identify early signs of cardiac dysfunction using advanced mechanocardiography.
Main Methods:
- Utilized complex mechanocardiography with digitized apexcardiography.
- Evaluated left ventricular performance at rest and during graded dynamic exercise.
- Compared 27 type 1 diabetic patients with 50 age- and sex-matched controls.
Main Results:
- No significant differences in resting diastolic/systolic functions were observed.
- Exercise revealed significantly prolonged corrected early apexcardiographic relaxation time in diabetics.
- Exercise showed a smaller normalized amplitude of relaxation in diabetics, indicating early diastolic disturbances.
- Diastolic disorders correlated with diabetes duration, not diabetic control.
Conclusions:
- Exercise-induced diastolic dysfunction can occur in type 1 diabetes patients without clinical symptoms or overt heart disease.
- Mechanocardiography after exercise is valuable for detecting these early diastolic abnormalities.
- Left ventricular systolic function may remain normal despite exercise-induced diastolic alterations.