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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Allergic Drug Reactions01:27

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Allergy to topical steroids.

Matthew Zirwas1

  • 1Ohio State University College of Medicine, Gahanna, OH, USA. matt.zirwas@osumc.edu

Journal of Drugs in Dermatology : JDD
|April 4, 2013
PubMed
Summary
This summary is machine-generated.

Topical steroid allergy (TSA) is common but frequently undiagnosed. This article discusses challenges in recognizing TSA and outlines diagnostic and treatment protocols.

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Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Topical steroid allergy (TSA) is an underdiagnosed condition.
  • It involves hypersensitivity to either the steroid molecule or vehicle ingredients.
  • TSA poses diagnostic and therapeutic challenges in clinical practice.

Purpose of the Study:

  • To elucidate the difficulties in the clinical recognition of TSA.
  • To present appropriate diagnostic protocols for TSA.
  • To outline effective treatment strategies for TSA.

Main Methods:

  • Review of clinical presentations of TSA.
  • Discussion of diagnostic approaches, including patch testing.
  • Analysis of treatment options for managing TSA.

Main Results:

  • Clinical recognition of TSA is often hindered by non-specific symptoms.
  • Accurate diagnosis requires a high index of suspicion and specialized testing.
  • Appropriate management involves identifying and avoiding allergens and alternative therapies.

Conclusions:

  • TSA is a significant cause of contact dermatitis, often overlooked.
  • Systematic diagnostic protocols are essential for accurate identification.
  • Effective management improves patient outcomes and quality of life.