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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Adherence to imported fire ant subcutaneous immunotherapy
Shayne C Stokes1, James M Quinn, Joshua J Sacha
1Division of Allergy and Immunology, Department of Medicine, Wilford Hall Medical Center, San Antonio, TX 78236, USA. shayne.stokes@us.af.mil
Summary
Patient adherence to imported fire ant (IFA) subcutaneous immunotherapy (SCIT) is crucial for its effectiveness. While many start IFA SCIT, long-term adherence remains low due to inconvenience and fear.
Area of Science:
- Allergy and Immunology
- Public Health
Background:
- Imported fire ant (IFA) subcutaneous immunotherapy (SCIT) is a safe and effective treatment for IFA allergy.
- Optimal protection requires monthly SCIT for 3-5 years, necessitating high patient adherence for successful outcomes.
Purpose of the Study:
- To evaluate SCIT adherence in patients with imported fire ant allergy in an endemic region.
- To identify factors influencing adherence to IFA SCIT.
Main Methods:
- Systemic reaction to IFA sting and detectable specific IgE were inclusion criteria.
- Demographic data and initial reaction severity were collected.
- Patients were assessed at 1 year for adherence, interval reactions, and reasons for nonadherence.
Main Results:
- 71% of patients initiated IFA SCIT, but only 35% remained adherent after 1 year.
- No significant differences in adherence were found based on age, sex, or initial reaction severity.
- Inconvenience and fear were primary reasons for nonadherence.
Conclusions:
- Despite being life-saving, IFA SCIT adherence is suboptimal, with significant drop-off after the first year.
- Logistical challenges and patient fear are major barriers to sustained adherence.
- Strategies to address inconvenience and fear are needed to improve IFA SCIT outcomes.
