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Updated: May 12, 2026
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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
Sequential healing of open extraction sockets. An experimental study in monkeys
Alessandro Scala1, Niklaus P Lang2, Michael T Schweikert3
1ARDEC, Ariminum Odontologica, Rimini, Italy.
Clinical Oral Implants Research
|April 5, 2013
Summary
This study details the natural healing of open tooth extraction sockets in monkeys. Bone formation and remodeling occur sequentially, closing the socket within a month and restoring alveolar structure over time.
Area of Science:
- Oral surgery
- Dental implantology
- Bone biology
Background:
- Open extraction sockets typically require surgical closure.
- Understanding spontaneous socket healing is crucial for regenerative dentistry.
Purpose of the Study:
- To describe the sequential healing process of open mandibular extraction sockets without primary closure.
- To provide a detailed timeline of socket healing morphometry.
Main Methods:
- Bilateral extraction of third mandibular premolars in 12 monkeys.
- No surgical closure of the extraction sockets.
- Morphometric analysis of healing at 4, 10, 20, 30, 90, and 180 days.
Main Results:
- Initial blood clot and inflammatory infiltrate at 4 days.
- Provisional matrix and new bone formation by 10 days, increasing by 20 and 30 days.
- Substitution of immature bone with trabecular bone and marrow by 90-180 days.
- Significant decrease in bundle bone from 95.5% to 7.6% over 180 days.
Conclusions:
- Alveolar socket closure is achieved through bone modeling from lateral and apical walls within one month.
- Subsequent remodeling leads to trabecular bone and marrow formation, with corticalization of the socket access.
