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Updated: May 12, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Interleukin 11 expression in the normal canine eye.

Tara R Richards¹, Jessica H H Mortlock, Chantale L Pinard

¹Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1.

Veterinary Ophthalmology

|April 5, 2013

Summary

This study reveals interleukin-11 (IL-11) is present in all canine cornea layers and its expression increases with TGF-β1, suggesting a role in ocular health and disease.

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Area of Science:

Ophthalmology
Immunology
Cytokine Research

Background:

Interleukin-11 (IL-11) is a cytokine with known anti-inflammatory and cytoprotective properties.
Understanding IL-11 expression in canine ocular tissues is crucial for diagnosing and treating eye conditions.

Purpose of the Study:

To characterize the expression of IL-11 in normal canine ocular tissues.
To investigate the regulation of IL-11 by TGF-β1 in canine corneal cells.

Main Methods:

Immunofluorescence was used to map IL-11 protein distribution in canine eye sections.
Quantitative RT-PCR and Western blot analysis assessed IL-11 mRNA and protein levels in cultured corneal cells.
Canine corneal cell lines were treated with TGF-β1 to evaluate its effect on IL-11 expression.

Keywords:

canine cornea epithelium interleukin-11 normal eye transforming growth factor beta

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Last Updated: May 12, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Main Results:

IL-11 protein was detected in the corneal epithelium, keratocytes, and endothelium.
Baseline IL-11 mRNA expression was confirmed in corneal epithelium, fibroblasts, and endothelium.
TGF-β1 significantly upregulated IL-11 expression in all tested corneal cell types, with the strongest induction in fibroblasts and endothelium.

Conclusions:

This study provides the first evidence of IL-11 expression in the canine eye.
IL-11 is constitutively expressed throughout the canine cornea.
TGF-β1 significantly enhances IL-11 expression in the canine cornea, highlighting its potential role in ocular inflammation and disease.