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Published on: February 10, 2015
Mastabol induced acute cholestasis: A case report.
Brett M Hymel1, David W Victor, Luis Alvarez
1Brett M Hymel, Department of Gastroenterology, Louisiana State University School of Medicine, New Orleans, LA 70112, United States.
World Journal of Hepatology
|April 5, 2013
Summary
This case study reports the first instance of cholestatic liver injury caused by the anabolic steroid Mastabol (Dromastanolone Di-Propionate). It emphasizes considering such substances in diagnosing unexplained hepatic issues.
Area of Science:
- Hepatology
- Toxicology
- Endocrinology
Background:
- Anabolic steroids are frequently misused for performance enhancement.
- Certain anabolic steroids, particularly those with 17 alpha-alkylation, are known to cause cholestatic liver injury.
- Mastabol (Dromastanolone Di-Propionate), a 17 beta-hydroxyl compound, was previously thought to have minimal hepatic toxicity.
Purpose of the Study:
- To report the first case of cholestatic liver injury associated with Mastabol (Dromastanolone Di-Propionate) use.
- To highlight the potential hepatotoxicity of injectable anabolic steroids.
- To emphasize the importance of considering anabolic steroid use in the differential diagnosis of drug-induced liver injury.
Main Methods:
- A case report of a 26-year-old male presenting with jaundice and elevated liver enzymes.
- Clinical presentation, laboratory findings (bilirubin, alkaline phosphatase, AST, ALT), and physical examination were documented.
- Liver biopsy was performed to assess the nature of the hepatic insult.
Main Results:
- The patient developed jaundice, dark urine, and pruritus after self-administering Mastabol.
- Liver function tests revealed elevated bilirubin (23.6 mg/dL) and alkaline phosphatase (441 U/L).
- Liver biopsy confirmed acute drug-induced cholestasis with centrilobular insult and neutrophilic infiltrates.
Conclusions:
- This is the first reported case of Mastabol-induced cholestatic liver injury.
- Physicians should consider anabolic steroid use, including injectable forms like Mastabol, in patients with unexplained hepatic injury.
- The findings suggest that even anabolic steroids without 17 alpha-alkylation may pose a risk for cholestatic liver injury.
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