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Updated: May 12, 2026

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Published on: August 1, 2018
A diverted total syntheses of potent cell adhesion inhibitor peribysin E analogues
Kishor L Handore1, D Srinivasa Reddy
1CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune, 411008, India.
Abstract:
Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (±)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of "diverted total synthesis" in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.
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