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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

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Related Experiment Video

Updated: May 12, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

New findings in genodermatoses.

Jonathan A Dyer1

  • 1Department of Dermatology, University of Missouri, 1 Hospital Drive, Room MA111D, Columbia, MO 65212, USA. dyerja@health.missouri.edu

Dermatologic Clinics
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

New DNA technologies are speeding up the discovery of genetic defects causing inherited skin diseases. This progress is accelerating the development of novel therapies for patients with these conditions.

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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Published on: December 14, 2015

Area of Science:

  • Genetics
  • Dermatology
  • Molecular Biology

Background:

  • Inherited skin diseases are caused by genetic defects.
  • Advances in genetic technologies are improving disease elucidation.
  • Therapeutic translation for these diseases is accelerating.

Purpose of the Study:

  • To summarize recent findings in genetic skin diseases.
  • To highlight advances in DNA analysis technologies.
  • To showcase the link between genetic understanding and therapeutic interventions.

Main Methods:

  • Review of recent genetic discoveries in skin diseases.
  • Analysis of the impact of new DNA sequencing technologies.
  • Case examples of genetic insights leading to therapies.

Main Results:

  • Accelerated elucidation of genetic defects in inherited skin diseases.
  • Growing number of genetic discoveries being translated into therapies.
  • Demonstrated success in developing targeted treatments based on genetic causes.

Conclusions:

  • Technological advancements are revolutionizing the study of genetic skin diseases.
  • Understanding the genetic basis is crucial for developing effective treatments.
  • The pace of therapeutic development for inherited skin diseases is increasing.