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Related Experiment Video

Updated: May 12, 2026

Embedded Bioprinting of Tissue-like Structures Using κ-Carrageenan Sub-Microgel Medium
04:58

Embedded Bioprinting of Tissue-like Structures Using κ-Carrageenan Sub-Microgel Medium

Published on: May 3, 2024

A tissue-like printed material.

Gabriel Villar1, Alexander D Graham, Hagan Bayley

  • 1Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.

Science (New York, N.Y.)
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

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Researchers created cooperating compartments using printed droplet networks, mimicking cellular cooperation for advanced materials. These synthetic tissues offer new possibilities in tissue engineering and bio-interfacing.

Area of Science:

  • Biomaterials Science
  • Synthetic Biology
  • Tissue Engineering

Background:

  • Living cells exhibit emergent properties through communication and cooperation, forming complex tissues.
  • Current synthetic cell mimics like liposomes lack the ability to cooperate, limiting their functional complexity.
  • Developing artificial systems that replicate cellular cooperation is a key challenge in biomaterials science.

Purpose of the Study:

  • To engineer cohesive materials with cooperating compartments using printed aqueous droplets.
  • To demonstrate the ability to create complex 3D structures with these droplet networks.
  • To explore functionalization and programming of droplet networks for advanced applications.

Main Methods:

  • Printing tens of thousands of picoliter aqueous droplets.

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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

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Last Updated: May 12, 2026

Embedded Bioprinting of Tissue-like Structures Using &#954;-Carrageenan Sub-Microgel Medium
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Embedded Bioprinting of Tissue-like Structures Using κ-Carrageenan Sub-Microgel Medium

Published on: May 3, 2024

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
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Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

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  • Joining droplets with single lipid bilayers to form cohesive networks.
  • Utilizing software-defined arrangements and osmolarity gradients for structural control.
  • Functionalizing droplet networks with membrane proteins for communication.

    • Main Results:

    • Formation of a cohesive material composed of cooperating picoliter droplets.
    • Successful construction of 3D structures using heterologous droplets in designed arrangements.
    • Demonstration of electrical communication pathways via membrane protein functionalization.
    • Programmable folding of droplet networks into complex structures using osmolarity gradients.

    Conclusions:

    • Printed droplet networks represent a novel approach to creating cooperating synthetic compartments.
    • These materials show potential as advanced tissue engineering substrates or mimics of living tissues.
    • The ability to form functional, structured networks opens avenues for bio-interfacing and synthetic biology applications.