Related Experiment Video
Updated: May 12, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
[Vitamin D and breast cancer: is there a link?]
F Stoll1, C Y Akladios, C Mathelin
1Pôle de gynécologie-obstétrique, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France. francois.stoll@gmail.com
Objective:
The aim of this review is to know the relationship between breast cancer and vitamin D, synthesised by skin or brought by food or supplementation.
Material And Methods:
The selected articles were extracted from the Pubmed database between 1998 and 2012. The keywords used were: "25-hydroxyvitamin D", "breast cancer recurrence", "breast cancer risk", "serum levels of vitamin D", "vitamin D intake". A total of 37 articles were selected.
Results:
The sun exposure, via the skin vitamin D synthesis, is associated with a decreased risk of breast cancer. This decrease seems also likely for food contributions and an over 400IU per day vitamin D supplementation. An inverse relationship between plasma 25-hydroxyvitamin D (25-OH-D) level and breast cancer risk has been suggested. An increased 25-OH-D level seems associated with a decreased risk of breast cancer recurrence.
Conclusion:
Recommendations concerning a vitamin D supplementation could be established, but should be supported by additional studies.
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