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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: May 12, 2026

Optimized Ex-ovo Culturing of Chick Embryos to Advanced Stages of Development

Optimized Ex-ovo Culturing of Chick Embryos to Advanced Stages of Development

Published on: January 24, 2015

Quality control of embryo development.

Anna Ajduk¹, Magdalena Zernicka-Goetz

¹Department of Embryology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland. aajduk@biol.uw.edu.pl

Molecular Aspects of Medicine

|April 9, 2013

Summary

This summary is machine-generated.

Improving in vitro fertilization (IVF) efficiency requires better embryo selection. This review compares methods for assessing embryo quality, highlighting advanced imaging techniques for selecting viable embryos.

Keywords:

Assisted reproduction technology (ART)Mammalian embryo Metabolomics Morphology grading Preimplantation genetic diagnosis/screening (PGD/PGS)Time-lapse imaging

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Area of Science:

Reproductive Biology and Medicine
Developmental Biology
Genetics and Genomics

Background:

In vitro fertilization (IVF) success rates remain suboptimal, often attributed to inaccurate pre-transfer embryo quality assessment.
Current IVF efficiency varies significantly (4-40%), necessitating improved methods for selecting embryos with higher developmental potential.
There is a critical need for advanced, non-invasive techniques to enhance embryo selection in clinical settings.

Purpose of the Study:

To review and compare existing and emerging methods for assessing preimplantation embryo quality.
To evaluate the information provided by different parameters regarding embryonic development.
To highlight novel techniques, such as advanced time-lapse imaging, for improving IVF outcomes.

Main Methods:

Comparative review of embryo quality assessment techniques.
Analysis of embryonic morphology, genetic material, transcriptomes (oocyte and follicular cells), and metabolism.
Evaluation of advanced time-lapse imaging technologies.

Main Results:

Current methods for embryo assessment have limitations in predicting developmental potential.
Analysis of transcriptomes and metabolism offers insights into intracellular processes.
Advanced time-lapse imaging shows significant promise for non-invasive, accurate embryo selection.

Conclusions:

Enhanced embryo selection is crucial for improving IVF efficiency.
A combination of morphological, genetic, and metabolic assessments, alongside advanced imaging, can optimize embryo selection.
Novel techniques, particularly time-lapse imaging, are expected to significantly increase IVF success rates.