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Updated: May 12, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Development of a chemical probe for identifying protein targets of α-oxoaldehydes
Christian Sibbersen1, Johan Palmfeldt, Jakob Hansen
1Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Abstract:
The development of a chemical probe for identifying the protein targets of reactive electrophilic α-oxoaldehydes such as methylglyoxal is presented. The probe is evaluated against methylglyoxal using human serum albumin as well as using living cells and lysates.
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