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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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Related Experiment Video

Updated: May 12, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

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Published on: August 5, 2014

Adiponectin and traumatic brain injury.

Satoru Takeuchi1, Kojiro Wada, Hiroshi Nawashiro

  • 1Department of Neurosurgery, National Defense Medical College, Saitama, Japan. s.takeuchi@room.ocn.ne.jp

Acta Neurochirurgica. Supplement
|April 9, 2013
PubMed
Summary

Adiponectin levels increase after traumatic brain injury in rats, suggesting this hormone may play a role in the brain

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Inflammation research

Background:

  • Adiponectin is an adipose-derived hormone with known cardiovascular benefits.
  • Its role in traumatic brain injury (TBI) is largely unexplored.
  • Potential therapeutic target for ischemic stroke, but TBI effects are unknown.

Purpose of the Study:

  • To investigate the immunoactivity and expression of adiponectin in a rat model of TBI.
  • To determine if adiponectin levels change following brain trauma.

Main Methods:

  • Adult male Sprague-Dawley rats were used.
  • Lateral fluid percussion injury model was employed.
  • Immunohistochemistry was performed to assess adiponectin expression.

Main Results:

  • Adiponectin expression increased in the cerebral cortex at 24 hours post-injury.
  • Adiponectin levels elevated in the hippocampus at 72 hours post-injury.

Conclusions:

  • Adiponectin expression is altered following traumatic brain injury in rats.
  • Adiponectin may be involved in the pathophysiological processes of TBI.