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Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case-control study
Pedro Enrique Jiménez Caballero1, Francisco Muñoz Escudero
1Department of Neurology, San Pedro de Alcántara Hospital, Avenida Pablo Naranjo 2, 1003, Cáceres, Spain. pjimenez1010j@yahoo.es
The Journal of Headache and Pain
|April 10, 2013
Summary
Chronic migraine patients exhibit endothelial dysfunction and increased arterial stiffness, suggesting a link between vascular health and migraine. This finding may inform new preventive treatments for migraine.
Area of Science:
- Neuroscience
- Vascular Biology
- Cardiology
Background:
- Migraine is a debilitating neurovascular disorder with strong evidence implicating nitric oxide in its pathophysiology.
- Endothelial dysfunction and arterial stiffness are potential contributors to migraine.
Purpose of the Study:
- To investigate the association between chronic migraine and ultrasonographic endothelial dysfunction.
- To assess arterial stiffness in chronic migraine patients using peripheral arterial tonometry.
Main Methods:
- Compared 21 chronic migraine patients with 21 healthy controls.
- Measured ultrasonographic endothelial function and augmentation index using peripheral arterial tonometry.
Main Results:
- Chronic migraine patients showed significantly lower peripheral arterial tonometry ratios (1.93 ± 0.39) compared to controls (2.21 ± 0.44, p=0.040).
- Patients with chronic migraine had a higher augmentation index (9.0 IQR: 4 to 12) than healthy controls (-6.0 IQR: 6.5 to -15, p=0.002).
Conclusions:
- Chronic migraine is linked to ultrasonographic endothelial dysfunction and increased arterial stiffness.
- Understanding the endothelial system's role in migraine may lead to novel preventive therapies and improved endothelial function restoration.
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