[Pemphigus vulgaris. Therapy with cyclophosphamide]
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Updated: May 12, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
L Vanstreels1, A Alkhateeb, M Megahed
1Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. lvanstreels@ukaachen.de
Abstract:
Pemphigus vulgaris is an autoimmune blistering disorder. The diagnosis is based on clinical presentation, histology, and direct and indirect immunofluorescence. Optimal treatment remains the greatest challenge. Treatment options include combinations of systemic steroids with azathioprine, mycophenolate, and cyclophosphamide. However, there is little solid data regarding the drug of choice. In our patient, the best tolerated and effective treatment was found after several therapeutic attempts.
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