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UP780, a chromone-enriched aloe composition improves insulin sensitivity.

Mesfin Yimam1, Jifu Zhao, Brandon Corneliusen

  • 1Unigen, Inc., Seattle, WA 98121, USA. myimam@unigen.net

Metabolic Syndrome and Related Disorders
|April 12, 2013
PubMed
Summary

This study shows that UP780, an aloe-based composition, effectively lowers blood glucose and insulin levels in diabetic mice. This natural product may help maintain healthy blood sugar in individuals with diabetes.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Products

Background:

  • Diabetic individuals often have high blood glucose, HbA1c, and insulin levels, alongside impaired glucose tolerance.
  • Adiponectin, a hormone inversely correlated with insulin resistance, plays a key role in glucose metabolism.
  • Aloesin, an aloe chromone, stimulates adiponectin production, potentially improving insulin sensitivity.

Purpose of the Study:

  • To investigate the glucose-lowering and insulin-sensitizing effects of aloesin and its formulated composition, UP780.
  • To evaluate UP780's efficacy in preclinical models of diabetes and obesity.

Main Methods:

  • In vitro testing of aloe chromones (aloesin, aloesinol) for adiponectin production.
  • Formulation of aloesin with an aloe polysaccharide into UP780.
  • Evaluation of UP780 efficacy in high-fat diet-induced and db/db obese-diabetic mouse models.
  • Comparison with a positive control, GW1929 (PPARγ agonist).

Main Results:

  • UP780 significantly reduced fasting triglyceride and plasma glucose levels in db/db mice.
  • Oral administration of UP780 decreased fasting blood glucose and plasma insulin levels in diabetic mice.
  • UP780 demonstrated statistically significant improvements in blood glucose clearance in both tested animal models.

Conclusions:

  • UP780, a chromone-standardized aloe composition, shows potential as a natural option for managing healthy blood glucose levels.
  • These findings support the use of aloe-based natural products in diabetes management.