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Updated: May 12, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

Biological functions of natural antisense transcripts.

Andreas Werner¹

¹RNA Interest Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, UK. Andreas.werner@ncl.ac.uk

|April 13, 2013

Summary

Natural antisense transcripts, originating from both DNA strands of protein-coding genes, are conserved across species. This widespread evolutionary conservation suggests potential biological functions for these natural antisense transcripts.

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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Published on: September 21, 2017

Area of Science:

Genomics
Molecular Biology
Transcriptomics

Background:

The human genome contains approximately 20,000 genes.
Genes are often clustered rather than evenly distributed.
Transcription from both DNA strands of protein-coding genes produces natural antisense transcripts (NATs).

Purpose of the Study:

To investigate the biological significance of natural antisense transcripts.
To explore the debate surrounding the functional role versus transcriptional noise of NATs.

Main Methods:

Analysis of gene clustering patterns in the human genome.
Examination of transcription from both DNA strands of protein-coding genes.
Assessment of evolutionary conservation of natural antisense transcripts.

Main Results:

Genes are frequently clustered in the genome.
Transcription occurs from both DNA strands for many protein-coding genes.
Natural antisense transcripts exhibit widespread evolutionary conservation.

Conclusions:

The evolutionary conservation of NATs suggests they are not merely transcriptional byproducts.
NATs likely possess important biological functions.
Further research is warranted to elucidate the roles of NATs.