Related Experiment Video
Updated: May 12, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
A thyroid incidentaloma detected by 18F-choline PET/CT
Giorgio Treglia1, Elisabetta Giovannini, Paoletta Mirk
1From the *Institute of Nuclear Medicine, †Institute of Radiology, ‡Department of Surgery, Division of Endocrine Surgery, Catholic University of the Sacred Heart, Rome; and §Department of Nuclear Medicine, University of Brescia, Brescia, Italy.
18F-choline PET/CT imaging detected an unexpected thyroid nodule, or incidentaloma, in a prostate cancer patient. Subsequent biopsy confirmed the thyroid incidentaloma was benign.
Area of Science:
- Nuclear Medicine
- Oncology
- Endocrinology
Background:
- 18F-choline Positron Emission Tomography/Computed Tomography (PET/CT) is utilized for prostate cancer staging and restaging.
- Incidentalomas are lesions discovered incidentally during medical imaging for other conditions.
Observation:
- A 66-year-old male patient with a history of prostate cancer underwent 18F-choline PET/CT for restaging purposes.
- The imaging revealed an area of increased 18F-choline uptake in the right lobe of the thyroid, corresponding to a hypodense nodule.
Findings:
- Fine-needle aspiration biopsy, guided by ultrasonography, was performed on the thyroid nodule.
- Histopathological analysis confirmed the presence of a benign thyroid nodule.
Implications:
- This case highlights the potential for 18F-choline PET/CT to detect thyroid incidentalomas in patients undergoing cancer evaluation.
- Awareness of this imaging characteristic is important for accurate interpretation and appropriate patient management, differentiating benign findings from potentially malignant lesions.
Related Concept Videos
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
