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Published on: August 16, 2018
Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
Magalí Pasqualone1, Tamara G Oberti, Héctor A Andreetta
1Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CONICET, CCT, La Plata, Argentina.
Journal of Materials Science. Materials in Medicine
|April 17, 2013
Summary
Novel copolymers were synthesized for potential use in transdermal delivery systems. Membranes made from poly(vinyl acetate-co-octan-2-yl fumarate) showed promising mechanical and swelling properties for drug delivery applications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Development of advanced materials for drug delivery is crucial.
- Copolymers offer tunable properties for specific applications.
- Transdermal delivery systems require biocompatible and mechanically stable membranes.
Purpose of the Study:
- To synthesize novel vinyl acetate and dialkylfumarate copolymers.
- To prepare and characterize membranes from these copolymers for transdermal delivery.
- To evaluate the properties of the membranes for potential drug delivery applications.
Main Methods:
- Radical copolymerization of vinyl acetate and dialkylfumarates (DIPF, DOF) under microwave irradiation.
- Characterization using NMR, FTIR, SEC, and DSC.
- Preparation of membranes supported on polyvinyl alcohol and evaluation of morphology, swelling, and mechanical properties.
Main Results:
- Successful synthesis of poly(vinyl acetate-co-dialkylfumarate) copolymers.
- Membranes exhibited non-Fickian water transport kinetics.
- Poly(vinyl acetate-co-octan-2-yl fumarate) membranes demonstrated good tensile strength, moderate swelling, and transparency.
Conclusions:
- The synthesized copolymers are suitable for membrane fabrication.
- Poly(vinyl acetate-co-octan-2-yl fumarate) membranes possess desirable characteristics for transdermal delivery.
- These membranes represent a promising platform for future transdermal drug delivery systems.
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