Related Experiment Video

Updated: May 12, 2026

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

Development of atopic disease and disturbed sleep in childhood and adolescence--a longitudinal population-based study

S Jernelöv1, M Lekander, C Almqvist

  • 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Susanna.jernelov@ki.se

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|April 23, 2013
PubMed

Insights

Childhood overtiredness and asthma symptoms may influence each other over time. This suggests a potential bidirectional relationship between atopic disease and sleep disturbances in children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Developmental Psychology
  • Sleep Medicine

Background:

  • Rising prevalence of atopic diseases and sleep disturbances in children.
  • Sleep's crucial role in immune regulation relevant to allergic conditions.
  • Established link between sleep issues, fatigue, and atopic disease, but causal pathways remain unclear.

Purpose of the Study:

  • Investigate developmental relationships between sleep disturbances and atopic disease symptoms.
  • Examine the time course of these conditions from childhood to adolescence.

Main Methods:

  • Longitudinal study using parent-reported data from the Twin Study of Child and Adolescent Development (TCHAD).
  • Data collected from 1480 twin pairs at ages 8-9 and 13-14.
  • Linked TCHAD data with the Swedish Medical Birth Register.

Main Results:

  • Overtiredness at age 8 increased risk of rhinitis at age 13 (OR 2.59).
  • Asthma symptoms at age 8 independently predicted overtiredness at age 13 (OR 2.64).
  • These associations remained significant after controlling for confounders.

Conclusions:

  • Findings support a more than passive interrelation between atopic disease and disturbed sleep.
  • Further research is needed to confirm causal relationships and developmental timing.
  • Clinicians should assess and treat sleep difficulties in pediatric patients with atopic conditions.
Abstract

More Related Videos

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...