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Taking sides: interferons in leprosy

Ludovic P Desvignes1, Joel D Ernst

  • 1New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA.

Cell Host & Microbe
|April 23, 2013
PubMed

In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection.

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