Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Mammary Glands01:12

The Mammary Glands

The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Switchable glycan probe enables pH-dependent activity modulation of UDP-glucose: glycoprotein glucosyltransferase through a responsive aglycone.

Chemical communications (Cambridge, England)·2026
Same author

Double-walled carbon nanotubes promote ASC speck formation and inflammasome activation in vascular endothelial cells.

Toxicology letters·2026
Same author

The association between work-family conflict and psychomotor vigilance among women working in aged care services in Japan.

Industrial health·2026
Same author

Notch interaction with RUNX factors regulates initiation of the T-lineage program.

The Journal of experimental medicine·2025
Same author

Considerations on the implementation of DCT: a SCAT-based analysis of fact-finding interviews in Europe and the United States, with implications for regions newly adopting DCT, including Japan.

Frontiers in medicine·2025
Same author

Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound.

ACS omega·2025

Related Experiment Video

Updated: May 12, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
09:49

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Published on: November 8, 2014

Mammary stroma in development and carcinogenesis.

Teruyo Sakakura1, Yuka Suzuki, Robert Shiurba

  • 1Mie University, Tsu-shi, Mie-ken, Japan. tsak@ztv.ne.jp

Journal of Mammary Gland Biology and Neoplasia
|April 23, 2013
PubMed
Summary

Mammary gland development involves complex interactions between epithelial and mesenchymal cells, regulated by hormones and growth factors. Understanding these stroma-epithelial dynamics is crucial for comprehending gland function and disease.

More Related Videos

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice
13:01

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice

Published on: August 12, 2011

Related Experiment Videos

Last Updated: May 12, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
09:49

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Published on: November 8, 2014

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice
13:01

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice

Published on: August 12, 2011

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Endocrinology

Background:

  • Mammary glands are complex organs composed of epithelial and mesenchymal cells.
  • Hormones, growth factors, and cytokines regulate mammary gland development and function.
  • Mammary gland development progresses through distinct stages from organogenesis to menopause.

Purpose of the Study:

  • To review the current understanding of stroma-epithelial interactions in mammary gland biology.
  • To highlight the role of mesenchymal cells in mammary gland development and function.
  • To explore the parallels between mammary gland morphogenesis and embryonic development.

Main Methods:

  • Review of existing literature on mammary gland biology.
  • Analysis of the roles of cell-cell interactions and signaling pathways.
  • Comparison of developmental processes in mammary glands with embryonic morphogenesis.

Main Results:

  • Epithelial and mesenchymal cells interact dynamically during mammary gland development.
  • Stroma-epithelial interactions are critical for forming the mature mammary gland structure.
  • Mammary gland development shares similarities with embryonic morphogenesis, including inflammation and tumorigenesis.

Conclusions:

  • Stroma-epithelial interactions are fundamental to mammary gland biology.
  • Mesenchymal cells play a vital role in guiding epithelial development and function.
  • Further research into these interactions can inform our understanding of mammary gland diseases.