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Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
Published on: June 16, 2011
Effects of mycotoxins on the mixed lymphocyte reaction
1Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Ichigaya, Shinjuku-ku, 162, Tokyo, Japan.
Mycotoxin Research
|April 23, 2013
Abstract:
Effects of toxic fungal metabolites on mixed lymphocyte reaction (MLR) using mouse splenocytes and on growth of mouse myeloma cells were examined. Among 25 toxins assayed, the IC50 values of emodin, luteoskyrin, sterlgmatocystin, deoxynivalenoi, 4-acetylnivalenol, T-2 toxin and fusaric acid for the MLR were lower than those for the cytotoxicity toward the myeloma cells, suggesting that these toxins possess suppressive activity to the cellular immune system.
