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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution
Line Pourtau1, Hugo Oliveira, Julie Thevenot
1Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France.
Advanced Healthcare Materials
|April 23, 2013
Abstract:
Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.

