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Identification and determination of selected histamine antagonists by densitometric method
Krystyna Czerwińska1, Elzbieta Wyszomirska, Aleksander P Mazurek
1Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chelmska St., 00-725 Warszawa, Poland. kczerwinska@il.waw.pl
Abstract:
The conditions for identification were determined for four histamine antagonists: clemastine fumarate, loratadine, cetirizine dihydrochloride and desloratadine by TLC (thin-layer chromatography) method. The selected chromatographic conditions were used to develop a densitometric method for the content determination of the histamine antagonists in medicinal products and substances. The statistical data showed adequate accuracy and precision of the developed methods.
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