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Related Experiment Video

Updated: May 12, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Chronic intestinal pseudo-obstruction.

Scott L Gabbard¹, Brian E Lacy

¹Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. Scott.L.Gabbard@hitchcock.org

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition

|April 25, 2013

Summary

This summary is machine-generated.

Chronic intestinal pseudo-obstruction (CIP) is a rare GI motility disorder causing bowel obstruction symptoms without a mechanical cause. Early diagnosis and nutrition support are crucial for managing this progressive condition.

Keywords:

enteral nutrition intestinal diseases intestinal pseudo-obstruction parenteral nutrition

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Last Updated: May 12, 2026

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

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Published on: September 11, 2012

Area of Science:

Gastroenterology
Motility Disorders
Rare Diseases

Background:

Chronic intestinal pseudo-obstruction (CIP) is a rare gastrointestinal (GI) motility disorder characterized by impaired peristalsis.
Symptoms mimic mechanical bowel obstruction, but no physical blockage is found.
CIP is often classified as a neuropathy, myopathy, or mesenchymopathy, with neuropathic causes being most common.

Observation:

CIP presents with nonspecific symptoms like dysphagia, abdominal pain, nausea, vomiting, bloating, and weight loss.
The small intestine is almost always affected, leading to significant patient distress.
Diagnostic challenges arise due to nonspecific symptoms and the focus on ruling out mechanical obstruction.

Findings:

The disorder is typically progressive, though secondary CIP may improve with treatment of the underlying cause.
Nutrition compromise is common, necessitating supplementation due to symptoms like dysphagia and weight loss.
Accurate diagnosis is often delayed because symptoms are nonspecific and mimic mechanical obstructions.

Implications:

This review emphasizes the importance of comprehensive nutrition assessment and treatment strategies for patients with CIP.
Understanding the epidemiology, etiology, pathogenesis, and diagnosis is key to improving patient outcomes.
Further research into CIP pathogenesis and effective treatments is needed to address this serious GI motility disorder.